Symbol
Name
ID

Plcg2
phospholipase C, gamma 2
MGI:97616

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Allergic rhinitis	Recurrent otitis media	Hashimoto thyroiditis	Antinuclear antibody positivity	Allergy	Asthma	Onychomycosis	Recurrent sinopulmonary infections
Disease(s) Associated with PLCG2
familial cold autoinflammatory syndrome 3

Mouse Phenotypes

immune system phenotype

increased B cell apoptosis

abnormal osteoclast differentiation

abnormal dendritic cell chemotaxis

decreased B cell proliferation

increased B cell proliferation

impaired macrophage phagocytosis

spleen hyperplasia

abnormal B cell differentiation

decreased transitional stage B cell number

increased immature B cell number

increased transitional stage T2 B cell number

increased pro-B cell number

arrested B cell differentiation

decreased mature B cell number

decreased B-1a cell number

decreased B-2 B cell number

decreased follicular B cell number

increased B-1a cell number

decreased pre-B cell number

increased pre-B cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased osteoclast cell number

abnormal dendritic cell morphology

abnormal B cell physiology

decreased IgM level

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

abnormal lymphatic vessel morphology

abnormal dendritic cell physiology

abnormal humoral immune response

decreased interferon-gamma secretion

decreased tumor necrosis factor secretion

decreased susceptibility to induced arthritis

abnormal inflammatory response

chronic inflammation

osteoarthritis

glomerulonephritis

dermatitis

increased susceptibility to Herpesvirales infection

Availability

Mouse Genotype

Plcg2^al/Plcg2^al

Plcg2^Ali5/Plcg2^Ali5

Plcg2^em1Msasn/Plcg2^em1Msasn

Plcg2^m1Btlr/Plcg2^m1Btlr

Plcg2^M2Btlr/Plcg2^M2Btlr

Plcg2^M3Btlr/Plcg2^M3Btlr

Plcg2^m4Btlr/Plcg2^m4Btlr

Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro

Plcg2^tm1Ichi/Plcg2^tm1Ichi

Plcg2^tm1Jni/Plcg2^tm1Jni

Plcg2^Ali5/Plcg2⁺

Plcg2^Ali14/Plcg2⁺

Plcg2^M2Btlr/Plcg2⁺

Plcg2^tm1Kuro/Plcg2^tm1Kuro
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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